MovDisordV3, Main, Exploration, bibRecord, 001152

Defining At-Risk Populations for Parkinson's Disease: Lessons From Ongoing Studies

Identifieur interne : 001152 ( Main/Exploration ); précédent : 001151; suivant : 001153

Defining At-Risk Populations for Parkinson's Disease: Lessons From Ongoing Studies

Auteurs : Daniela Berg [Allemagne] ; Ken Marek [États-Unis] ; George W. Ross [États-Unis] ; Werner Poewe [Autriche]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0223365

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Facteur risque, Asymptomatique.

English descriptors

KwdEn :
- Asymptomatic, Nervous system diseases, Parkinson disease, Risk factor.

Abstract

It is currently widely acknowledged that the natural history of PD includes a preclinical phase, and there are increasing efforts to identify markers that would allow the identification of individuals at risk for PD. Here, we discuss the issues related to defining at-risk populations for PD and review findings of current population-based cohorts that have reported potential biomarkers for PD, such as the Honolulu-Asia Aging Study (HAAS) and the PRIPS (Prospective Validation of Risk factors for the development of Parkinson Syndromes) study. We also discuss enriched risk cohorts designed to evaluate specificity and predictive value of markers exemplified by the PARS (Parkinson Associated Risk Study) and the TREND (Tubinger evaluation of Risk factors for the Early detection of NeuroDegeneration) study. Although there is still a long way to go, studies designed according to these concepts might eventually provide sufficient data to form the basis for future screening programs for PD risk to be applied at a population level.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000202
to stream PascalFrancis, to step Curation: 002B12
to stream PascalFrancis, to step Checkpoint: 000225
to stream Main, to step Merge: 001204
to stream Main, to step Curation: 001152

Le document en format XML

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<front><div type="abstract" xml:lang="en">It is currently widely acknowledged that the natural history of PD includes a preclinical phase, and there are increasing efforts to identify markers that would allow the identification of individuals at risk for PD. Here, we discuss the issues related to defining at-risk populations for PD and review findings of current population-based cohorts that have reported potential biomarkers for PD, such as the Honolulu-Asia Aging Study (HAAS) and the PRIPS (Prospective Validation of Risk factors for the development of Parkinson Syndromes) study. We also discuss enriched risk cohorts designed to evaluate specificity and predictive value of markers exemplified by the PARS (Parkinson Associated Risk Study) and the TREND (Tubinger evaluation of Risk factors for the Early detection of NeuroDegeneration) study. Although there is still a long way to go, studies designed according to these concepts might eventually provide sufficient data to form the basis for future screening programs for PD risk to be applied at a population level.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Defining At-Risk Populations for Parkinson's Disease: Lessons From Ongoing Studies

Defining At-Risk Populations for Parkinson's Disease: Lessons From Ongoing Studies

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri